个人简介

徐建国，教授，工学博士，博士后，硕士生导师。2017.6-2023.8在合肥工业大学食品与生物工程学院从事教学、科研工作，2023年9月引进到嘉兴大学，入选“南湖学者”特聘教授、嘉兴市“星耀南湖”青年领军人才计划。主要从事功能核酸及CRISPR/Cas增敏感知体系构建，致力于食品安全危害因子、疾病标志物分析及环境危害物检测等方面的基础及应用研究，主持包括国家自然科学基金、浙江省自然科学基金重点项目、安徽省重点研发计划/面上/青年基金、中国博士后面上基金等科研项目10余项。已在Anal. Chem.（16篇）、Adv. Sci.、Biomaterials.、Biosens. Bioelectron.、J. Hazard. Mater.、J. Agric. Food Chem.、Food Chem.、Crit. Rev. Food Sci.、Chem. Commun.等期刊发表第一作者和通讯作者SCI收录论文50余篇（https://orcid.org/0000-0002-0187-2623），参与制定地方标准3项，授权发明专利3项（转化1项），参编中英文专著2部。兼任《Journal of Analysis and Testing》青年编委、《分析试验室》编辑/编委，为Acs Nano、Adv. Fun. Mater、JACS Au、Nano Today、Small、Anal. Chem.、ACS Sens.、Biosens. Bioelectron.、Chem. Commun.、J. Agri. Food. Chem.、Food Chem.等领域内多种期刊审稿人。

Email: jgxu0816@163.com;

工作经历

研究方向

(1)功能核酸探针设计与分子增敏感知平台构建

(2)食品安全危害因子/疾病标志物/环境危害物分析检测

(3)病原体检验检疫/抗菌技术构建、食品真实性鉴定

主持科研项目

(1)浙江省自然科学基金重点项目，Z25C200003，2025.1.1-2027.12.31，主持

(2)国家自然科学基金青年基金项目，21804028，2019.01-2021.12，主持

(3)安徽省重点研发计划项目，202004h07020029，2020.01-2022.12，主持

(4)安徽省自然科学基金面上项目，2308085MB57，2023.9-2026.8，主持

(5)安徽省重点研发计划项目，202104a07020008，2021.1-2023.12，子课题主持

(6)安徽省重点研发计划项目，2022e07020060，2022.1-2024.12，子课题主持

(7)安徽省自然科学基金青年项目，1908085QC121，2019.07-2021.06，主持

(8)中国博士后基金面上项目，2019M652167，2019.06-2021.01，主持

(9)嘉兴市社会发展专项，2025BS009，2025.04-2028.04，主持

代表性论文

(1)Zhuqi Sui, Baoqiang Chen, Jia Zhao, Ruijie Deng, and Jianguo Xu*. Pronounced Fluorescence Polarization Enhancement Driven by RPA-CRISPR/Cas12a Induced Nucleoprotein Assembly for Salmonella Analysis in Animal-Derived Food Matrices. Anal. Chem., 2026, 98, 10, 7822-7831

(2)Jia Zhao, Zhuqi Sui, Yu Zhou*, Yubo Peng, and Jianguo Xu*. Rigidity-Responsive Fluorescence Polarization Detection of Aflatoxin B1 via Programmable RCA-Coupled CRISPR/Cas12a and a Conformation-Restricted Depolarization Reporter. Anal. Chem., 2026, 10.1021/acs.analchem.6c00481

(3)Jia Zhao, Zhuqi Sui, Yi Wang, Haiyan Dong, Baoqiang Chen, and Jianguo Xu*. Programmable Dual-Phase Electrochemical Biosensor Combines Homogeneous CRISPR/Cas12a Activation with Interfacial Poly-G Signaling for miRNA-21 Detection. Anal. Chem., 2025, 97, 37, 20515-20526

(4)Zhuqi Sui, Baoqiang Chen, Jia Zhao, Haidong Yang, Longhua Guo, and Jianguo Xu*. Self-Sustaining miRNA Amplification Diagnostics via Catalytic Hairpin Assembly and Split Activator-Initiated CRISPR/Cas12a Hybrid Feedback Circuit with Target Regeneration and Recycling. Anal. Chem., 2025, 97, 31, 17076-17084

(5)Qi Wang, Shuo Yang, Xiumei Chen, Shihui Song, Yan Wu, Yang Li, Xiang Meng, Luyang Dai, Zheng Yang, Hanlin Wu, Juan Xia, and Jianguo Xu*. Mutually Activated Dual-Exponential Amplification DNA Machine Enhances Robust CRISPR/Cas12a Feedback Propagation for Ultrasensitive miRNA Detection. Anal. Chem., 2025, 97, 25, 13504-13513

(6)Zhuqi Sui, Baoqiang Chen, Jia Zhao, Haidong Yang, Longhua Guo, and Jianguo Xu*. Dual-Accelerated Signal Amplification in Biosensing via Spatial Confining Catalytic Hairpin Assembly-Activated Spherical CRISPR/Cas12a System for Trans-Cleavage of Hairpin DNA Reporters. Anal. Chem., 2025, 97, 8, 4668-4677

(7)Qi Wang, Juan Xia, Chengying Yang, Xiumei Chen, Baoqiang Chen, Yang Li, Hong Huang, Bingyong Lin, Longhua Guo, and Jianguo Xu*. Cross-Priming-Linked Hierarchical Isothermal Amplification Programming Progressive Activating Clustered Regularly Interspaced Short Palindromic Repeats/Cas12a in miRNA Signaling. Anal. Chem., 2024, 96, 35, 14205-14214.

(8)Qi Wang, Baoqiang Chen, Dan Zheng, Juan Xia, Lijun Wu*, and Jianguo Xu*. Intramolecular Accelerated Assembly of Molecular Beacons: A DNA Nanoarchitecture-based Spatial Confinement Strategy toward Terminal Deoxynucleotidyl Transferase Biosensing. Anal. Chem., 2023, 95, 13708-13715.

(9)Xinlei Zhang, Yubo Peng, Li Yao, Huijie Shang, Zhi Zheng, Wei Chen*, and Jianguo Xu*. Self-Assembly of Multivalent Aptamer-Tethered DNA Monolayers Dedicated to Fluorescence Polarization-Responsive Circular Isothermal Strand-Displacement Amplification for Salmonella Assay. Anal. Chem., 2023, 95, 2570-2578

(10)Huijie Shang, Yubo Peng, Li Yao, Zhi Zheng, Hongxia Li, Wei Chen*, Jianguo Xu*. Self-Customized Multichannel Exponential Amplifications Regulate Powered Monitoring of Terminal Deoxynucleotidyl Transferase Activity. Anal. Chem., 2022, 94, 32, 11401-11408

专著及专利

(1)《食品安全学》，郑州大学出版社，编委，2019年12月

(2)Jianguo Xu, Li Yao, Lin Cheng, Chao Yan, and Wei Chen*. “Development of Aptamer-Based Electrochemical Methods.” Aptamers for Analytical Applications: Affinity Acquisition and Method Design, Willey publishing, 2018: 247-271.

(3)徐建国, 陈伟, 张鑫磊, 姚丽, 尚慧杰, 彭育勃. “一种功能性核酸探针及其制备方法与应用”. 中国发明专利, ZL 2022 1 1312408.3, 授权公告日: 2025年11月21日.

(4)徐建国, 陈伟, 秦盼柱, 闫超, 张超, 王昕昕, 高岩. “一种双重 DNA 机器检测 microRNA-21 的方法”. 中国发明专利, ZL 2019 1 0288202.3, 授权公告日: 2023年01月31日.

(5)徐建国, 陈伟, 闫超, 秦盼柱, 姚丽. “一种检测 microRNA-21 的电化学传感器、其制备方法及应用”. 中国发明专利, ZL 2018 1 1523457.5, 授权公告日: 2021年01月01日.